Tamoxifen and Breast Cancer

Tamoxifen and Breast Cancer

This edition contains information on developments in the use of tamoxifen, especially in the results of the Breast Cancer Prevention Trial.

Author: Michael W. DeGregorio

Publisher: Yale University Press

ISBN: 0300079516

Category: Medical

Page: 132

View: 613

A discussion of the diagnosis of breast cancer and the risks, benefits and limitations of treatment alternatives, particularly tamoxifen. This edition contains information on developments in the use of tamoxifen, especially in the results of the Breast Cancer Prevention Trial.
Categories: Medical

Tamoxifen Concepts and Cancer

Tamoxifen Concepts and Cancer

However, further considerations exist regarding the tamoxifen profile. This book discusses recent research and future perspectives in the tamoxifen field.

Author: Ramon Andrade De Mello

Publisher: Nova Science Pub Incorporated

ISBN: 1620815206

Category: Medical

Page: 209

View: 688

Tamoxifen was first approved in 1977 and up to now remains a noteworthy therapeutic weapon to treat mainly breast cancer. However, further considerations exist regarding the tamoxifen profile. This book discusses recent research and future perspectives in the tamoxifen field. The topics discussed include tamoxifen pharmacokinetics, pharmacodynamics, adverse effects, clinical indications, therapeutic drug monitoring, autophagy mechanisms, tamoxifen topical formulation and breast cancer risk prevention, the use of tamoxifen in an oestrogen-independent manner for various neoplasms (Hepatocellular carcinoma, renal cell carcinoma, high grade glioma), mechanisms of resistance, potential role of CYP2D6, tamoxifen and antidepressants interaction in a psychiatric view, obesity influence in tamoxifen treatment, electrical pulse-mediated tamoxifen delivery, and tamoxifen in melanoma treatment.
Categories: Medical

Long term Tamoxifen Treatment for Breast Cancer

Long term Tamoxifen Treatment for Breast Cancer

In this volume, editor V. Craig Jordan provides articles that trace the development, pharmacology, and clinical research surrounding this drug which, by the year 2000, could be used to treat as many as one million women annually.

Author: Virgil Craig Jordan

Publisher: Univ of Wisconsin Press

ISBN: 0299140709

Category: Medical

Page: 320

View: 598

During the past twenty years tamoxifen has become the most widely prescribed and most successful drug used in the treatment of breast cancer. In this volume, editor V. Craig Jordan provides articles that trace the development, pharmacology, and clinical research surrounding this drug which, by the year 2000, could be used to treat as many as one million women annually. Drawing from research conducted by specialists in the United States, the United Kingdom, and Italy, the series of articles describes the clinical testing of tamoxifen, highlighting the benefits. Studies show that tamoxifen lowers cholesterol and can potentially protect women against osteoporosis and fatal coronary heart disease. Equally important is a discussion of side effects and possible drug interactions and how these issues relate to patient concerns. An investigation of the development of a new class of drugs for use after tamoxifen fails provides valuable insight into future treatments, as the contributers consider possible resistance to tamoxifen. This volume provides invaluable information for physicians and surgeons who care for patients with breast cancer and for women interested in exploring this therapeutic dimension. "
Categories: Medical

Tamoxifen

Tamoxifen

Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor.

Author: Philipp Y. Maximov

Publisher: Springer

ISBN: 303480783X

Category: Medical

Page: 202

View: 856

Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the “father of tamoxifen” - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a “failed morning after contraceptive” to become the “gold standard” for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen’s pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.
Categories: Medical

Influence of Radiotherapy and Tamoxifen on Contralateral Cancer Risk in Women with Hereditary Breast Cancer

Influence of Radiotherapy and Tamoxifen on Contralateral Cancer Risk in Women with Hereditary Breast Cancer

In the present funding period, in accordance with the Statement of Work, continued review of clinical records was performed, with identification of pathology blocks that will be cut to provide the samples for genotyping.

Author: Mark E. Robson

Publisher:

ISBN: WISC:89081537870

Category:

Page: 18

View: 848

Women with breast cancer arising as a consequence of germline mutations in BRCA1 or BRCA2 are at significant risk of contralateral breast cancer (CBC). Examination of factors influencing contralateral risk will provide insight into prevention strategies for unaffected women with BRCA mutations. A combined analysis performed with the JGH indicates tamoxifen may reduce CBC risk by 53% (attached). To evaluate CBC risk factors, the funded study is assessing the impact of tamoxifen and radiotherapy on CBC risk. In the present funding period, in accordance with the Statement of Work, continued review of clinical records was performed, with identification of pathology blocks that will be cut to provide the samples for genotyping. Medical records from 1990 and 1991 were not reliably retrievable, leading us to expand the cohort eligibility dates to 199E. As of this report, we have reviewed 692 records in this interval, of whom 453 are eligible and for whom data has been entered. Data cleaning is in process and acquisition of tissue samples will begin shortly, followed by genotyping after anonymization. Combining these data with our original cohort of 329 cancers in 305 patients (JNCI 1999), we will have achieved 78% of our accrual goal of 1000 cases.
Categories:

Tamoxifen

Tamoxifen

Now, in this comprehensive, accessible guide, a medical doctor provides answers to the critical questions every woman should ask before considering preventive therapy or cancer treatment with tamoxifen.

Author: John F. Kessler

Publisher: Avon

ISBN: 038081028X

Category: Medical

Page: 208

View: 931

On the market in the United States since 1978, tamoxifen is the most widely prescribed anti-cancer drug in the world. Recently, this powerful cancer fighter has been found to prevent breast cancer, and its use as a breast cancer preventive has been approved by the FDA. For women at high risk of breast cancer, tamoxifen provides a new option for prevention of this disease. Now, in this comprehensive, accessible guide, a medical doctor provides answers to the critical questions every woman should ask before considering preventive therapy or cancer treatment with tamoxifen. Should I consider myself at high risk of breast cancer? Do the risks of breast cancer outweight the risks of taking tamoxifen? How does tamoxifen compare with other prevention therapies? What are the side effects of tamoxifen? How long do I have to take this drug? Is research continuing on the use of tamoxifen as a preventive? And Much, Much More!
Categories: Medical

Tamoxifen and Breast Cancer

Tamoxifen and Breast Cancer

Author: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies

Publisher:

ISBN: STANFORD:36105119595309

Category: Breast

Page: 60

View: 529

Categories: Breast

Tamoxifen Tales

Tamoxifen Tales

This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry.

Author: V. Craig Jordan

Publisher: Academic Press

ISBN: 9780323859721

Category: Business & Economics

Page: 312

View: 626

Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan’s 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women’s healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career. Highlights lessons learned from the journey behind discovery science that are applicable to the scientific journey of the next generation of scientists Provides a manual on the successful mentoring of young scientists to become leaders in academia and the pharmaceutical industry Examines cancer treatment based on a personal determination to challenge at the frontiers of the science and to relate to personal life experience Includes references for further research reading
Categories: Business & Economics

Estrogen Action Selective Estrogen Receptor Modulators and Women s Health

Estrogen Action  Selective Estrogen Receptor Modulators and Women s Health

This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators).

Author: V Craig Jordan

Publisher: World Scientific

ISBN: 9781848169593

Category: Science

Page: 544

View: 940

This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs — tamoxifen and raloxifene — are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future. Contents:A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention (V Craig Jordan)Diethylstilbestrol: A Tragedy in Reproductive Endocrinology But a Pioneering Cancer Treatment (Joan Lewis-Wambi and V Craig Jordan)Oral Contraceptives and Women's Health (V Daniel Castracane and V Craig Jordan)Hormone Replacement Therapy and Women's Health (Jennifer Eng-Wong, Ifeyinwa Obiorah and V Craig Jordan)Induction of Ovulation by Nonsteroidal Antiestrogens (Ifeyinwa Obiorah and V Craig Jordan)Clues About Estrogen and Antiestrogen Action from X-Ray Crystallography (Geoffrey L Greene and V Craig Jordan)Coregulators and Their Role in Selective Estrogen Receptor Modulator Action (Christopher D Chien, Anton Wellstein and Anna Riegel)Role of Estrogen in Familial Breast Cancer (Eliot Rosen and Claudine Isaacs)Advances with Aromatase Inhibitors (Saranya Chumsri, Ting Bao, Gauri Sabnis and Angela Brodie)Adjuvant Antihormone Therapy (Anthony Howell and V Craig Jordan)Pharmacogenomics of Tamoxifen (Hiltrud B Brauch and V Craig Jordan)Antihormone Drug Resistance (Robert Clarke and V Craig Jordan)Novel Selective Estrogen Receptor Modulators (Surojeet Sengupta and V Craig Jordan)Endocrine Prevention of Breast Cancer (Trevor J Powles, Russell E McDaniel and V Craig Jordan)Selective Androgen Receptor Modulators as Improved Androgen Therapy for Women (Christopher C Coss and James T Dalton)An Emerging Principle: Selective Nuclear Receptor Modulators (Ping Fan and V Craig Jordan) Readership: Clinicians, biological faculty, informed patients, scientists and students in biology and medicine, healthcare and medical professionals, breast cancer survivors. Keywords:Estrogen;Women's Health;SERMs;Breast Cancer;Tamoxifen;Raloxifene;DESKey Features:A unique easy-to-read book for clinicians, biological faculty, informed patients, scientists and medical professionalsFocuses on the evolution of estrogen action in women's health and changes in healthcare through scientific researchA concise summary of progressNo other competing titles of the same caliberWritten by the pioneers in the field
Categories: Science