Medicine is the science of diagnosis, prognosis and treatment of diseases. In order to prevent or treat diseases, one needs to understand causal mechanisms underlying the (mal)functioning of the human body, its organ systems, tissues, ...

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Publisher: Academic Press

ISBN: 9780128160787

Category: Science

Page: 1589

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Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

10 Analytic methods for systems medicine Panagiotis V.S. Vasileiou 1, Gkikas Magiorkinis 2, Pagona Lagiou 2,3, Vassilis Gorgoulis 1,4,5,6 1Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, ...

Author: Stephen Sonis

Publisher: Academic Press

ISBN: 9780128137635

Category: Medical

Page: 458

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Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

Systems medicine: the future of medical genomics and healthcare. Genome Med. 1:2. doi: 10. 1186/gm2 Barabási, A. L., and Oltvai, Z. N. (2004). Network biology: understanding the cell's functional organization. Nat. Rev. Genet.

Author: Adil Mardinoglu

Publisher: Frontiers Media SA

ISBN: 9782889451401

Category: Electronic book

Page: 98

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Complex disorders including obesity, diabetes, fatty liver disease, cardiovascular disease and cancer are results from a combination of genetic, environmental and lifestyle factors. The prevalence of such disorders has increased dramatically in the last two decades and there is an urgent need for the development of new prognostic tools for the treatment of such diseases. However, this requires a deep understanding of the underlying molecular mechanisms involved in the occurrence of the diseases. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties. This inter-disciplinary field of study allows for understanding biological processes of cells in health and disease states, gaining new insights into what drives the appearance of the disease and finally identifying proteins and metabolites implicated in human disease. Systems medicine utilizes mathematical approaches to generate models which can be employed for designing new sets of experiments and for mapping the response of the system to perturbations quantitatively. These models as well as the developed tools can accelerate the emergence of personalized medicine which can transform the practice of medicine and offer better targets for drug development with minimum side effects.

Systems medicine: the future of medical genomics and healthcare. Genome Med. 1 (1), 2. Avner, B.S., Fialho, A.M., Chakrabarty, A.M., 2012. Overcoming drug resistance in multidrug resistant cancers and microorganisms: a conceptual ...

Author: Qing Yan

Publisher: Academic Press

ISBN: 9780128043882

Category: Computers

Page: 182

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Translational Bioinformatics and Systems Biology Methods for Personalized Medicine introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine. Through the description of important cutting-edge technologies in bioinformatics and systems biology, readers may gain an essential understanding of state-of-the-art methodologies. The book discusses topics such as the challenges and tasks in translational bioinformatics; pharmacogenomics, systems biology, and personalized medicine; and the applicability of translational bioinformatics for biomarker discovery, epigenomics, and molecular dynamics. It also discusses data integration and mining, immunoinformatics, and neuroinformatics. With broad coverage of both basic scientific and clinical applications, this book is suitable for a wide range of readers who may not be scientists but who are also interested in the practice of personalized medicine. Introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine Presents a problem-solving oriented methodology to deal with practical problems in various applications Covers both basic scientific and clinical applications in order to enhance the collaboration between researchers and clinicians Brings integrative and multidisciplinary approaches to bridge the gaps among various knowledge domains in the field

Figure 13.3 Systems medicine toward implementation of P4 medicine and a paradigm shift in healthcare. Figure 14.1 The end‐to‐end knowledge discovery (KDD) process. This figure. Clinical trials Methodology and technology Academia ...

Author: Antonia Vlahou

Publisher: John Wiley & Sons

ISBN: 9781119183976

Category: Science

Page: 384

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Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed. Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting. Describes a range of state of the art omics analytical platforms Covers all aspects of the systems biology approach—from sample preparation to data integration and bioinformatics analysis Contains specific examples of omics methods applied in the investigation of human diseases (Chronic Kidney Disease, Bladder Cancer) Integration of omics Approaches and Systems Biology for Clinical Applications will appeal to a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, and bioinformaticians working on the different molecular platforms. It is also an excellent text for students interested in these fields.

REFERENCES Bloch , D. Family systems medicine : The field and the journal . Family Systems Medicine , 1983 , 1 , 3-11 . Bursztajn , H. , Feinbloom , R. , Harum , R. , & Brodsky , A. Medical choices , medical changes .

Author: Lyman C. Wynne

Publisher: Guilford Press

ISBN: 089862908X

Category: Psychology

Page: 514

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Systems Consultation challenges two basic assumptions of family therapy: first, that what family therapists should be doing is curing pathology; second, that family interactions can be understood by focusing on families to the exclusion of larger systems. In asking whether therapy is the best and only model for what family therapists do, this book registers a definitive no. In its place it offers a systems consultation role that more accurately captures the range of activities therapists can and currently do engage in.

13.1.4 Analysis of Cells at System Level The system level provides the information at all the points of cell function. ... 13.2.1 Systems Medicine Systems medicine is based on systems biology and systems science.

Author: Nosheen Masood

Publisher: Springer Nature

ISBN: 9789811510670

Category: Medical

Page: 499

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This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

The concept of systems biology is applied to systems medicine and is relevant to personalized medicine. Computational and mathematical tools have enabled the development of systems approaches for deciphering the functional and ...

Author: Kewal K. Jain

Publisher: Humana Press

ISBN: 9781493925537

Category: Medical

Page: 732

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Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

make it possible to recognise health risks at an early stage and develop appropriate health strategies.205 Systems Medicine The term “Systems Medicine” describes the application of Systems Biology approaches to medical research and drug ...

Author: Karin Bosshard

Publisher: Springer

ISBN: 9783658220747

Category: Law

Page: 411

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The book adds to the discussion about strategic approaches towards the translation of personalized medicine into clinical practice. It stresses the importance of non-science related, institutional barriers. A Law and Economics perspective is applied in order to examine the incentives induced by the barriers. An applied part identifies and evaluates policy levers to foster the translation of personalized medicine into Swiss clinical practice.

These five levels of involvement with family Systems medicine clearly emphasize the variability in the degree of family orientation among practices. Today, family practice residencies are beginning to place increased emphasis on family ...

Author: John L. Buckingham

Publisher: Springer Science & Business Media

ISBN: 9781475719987

Category: Medical

Page: 677

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New material in a new format is contained in this third edition of Family Medicine. The comprehensive text nevertheless remains true to the goal of previous editions in offering a scientific approach to health and illness within the context of the family. Using up-to-date clinical material, the book demonstrates how the family physician may provide comprehensive health care to persons of all ages. The first part of Family Medicine discusses such topics as the conceptual basis of family as discipline and specialty, problem differentiation, family-centered health care, longitudinal care, clinical reasoning, and resource management. The second part explores both problems related to organs and systems and problems related to the person, family and community, including: pregnancy, care of infants, children, adolescents, and the elderly; behavioral and psychiatric problems; emergency and critical care; sports medicine; alcoholism and substance misuse; environmental health; and neoplastic and infectious diseases. Family Medicine, with its greatly expanded in-depth coverage of the most commonly encountered clinical core problems and procedures in family medicine, continues to be a textbook written and edited by family physicians for family physicians.