Inflammatory Bowel Diseases New Developments and Standards

Inflammatory Bowel Diseases  New Developments and Standards

In addition , the observation that the dizygotic twin concordance rate in IBD is of the same order of magnitude as the sibling recurrence risks11 also argues that , if environmental factors are important , they are likely to be ...

Author: W.E. Fleig

Publisher: Springer Science & Business Media

ISBN: 0792388909

Category: Medical

Page: 344

View: 540

Falk Symposium No. 82, held in Halle, Germany, November 1994, focuses on the advances made in understanding the aetiology and pathogenesis of inflammatory bowel disease (IBD). Sections of this book, the Proceedings of the conference, are devoted to extraintestinal manifestations, cancer development, IBD in the context of pregnancy, and the assessment of disease activity, prognosis and quality of life. The second half of the book is devoted to the discussion of standards and new developments in diagnosis, conservative management and surgery. Audience: All clinicians and basic scientists working in the field of IBD.
Categories: Medical

Inflammatory Bowel Disease Translation from Basic Research to Clinical Practice

Inflammatory Bowel Disease  Translation from Basic Research to Clinical Practice

Trends in Inflammatory Bowel Disease Therapy . Falk Symposium No. 66. ... Inflammatory Bowel Diseases – Pathophysiologyas Basis of Treatment . Falk Symposium No. 67. ... Inflammatory Bowel Diseases : New Developments and Standards .

Author: B. Vucelic

Publisher: Springer Science & Business Media

ISBN: 1402028474

Category: Medical

Page: 314

View: 653

The amount of information on the pathogenesis of inflammatory bowel disease is growing rapidly. This is reflected by a continuous increase in the number of papers presented at international GI meetings. To make things more difficult for practicing physicians, there is also a large number of new clinical trials being published which require periodical critical reviews and recommendations. Faced with these issues, the scientific commitee of the Falk Symposium No. 140 decided to take a different approach and to apply a novel format that is reflected in the title of the Symposium: "Translation from basic research to clinical practice". This book contains the proceedings of that Symposium, held in Dubrovnik, Croatia, on May 7–8, 2004. The sections are designed so that they start with the information from basic sciences on different aspects of these complex diseases and further lead to their clinical implications. Special attention is paid to the mechanisms of actions of established drugs. The last two sections are clinically oriented and focus on the most difficult aspects of both Crohn's disease and ulcerative colitis. This format provides state-of-the-art chapters by leading experts in the field and at the same time up-to-date information on the clinical application of the new knowledge.
Categories: Medical

Immunosuppression in Inflammatory Bowel Diseases

Immunosuppression in Inflammatory Bowel Diseases

This volume is the Proceedings of Falk Symposium 119 held in Freiburg-im-Breisgau, Germany, October 3-4, 2000, and covers systematically the field of immunosuppression in inflammatory bowel diseases.

Author: K. Fellermann

Publisher: Springer Science & Business Media

ISBN: 0792387678

Category: Medical

Page: 288

View: 644

The aetiology of the chronic inflammatory bowel diseases - Crohn's disease and ulcerative colitis - is still enigmatic. The therapeutic approach has therefore traditionally focused on anti-inflammatory principles, including corticosteroids and aminosalicylates. Since a significant proportion of patients is steroid-dependent or refractory and because of the problematic side-effects of long-term systemic steroids, active immunosuppression has gained acceptance in the field. The classical immunosuppressants azathioprine and 6-mercaptopurine have long been evidence-based in IBD, but underused. Recently, methotrexate and cyclosporine have also been proven to be effective in certain situations. Newer drugs like tacrolimus, mycophenolate and others may be similarly useful but their potential is still unclear. Finally, the immune modifiers including IL-10 and TNF-antibodies have been successfully subjected to controlled trials. Other experimental drugs discussed in this book are on the horizon. This volume is the Proceedings of Falk Symposium 119 held in Freiburg-im-Breisgau, Germany, October 3-4, 2000, and covers systematically the field of immunosuppression in inflammatory bowel diseases. It is hoped that it will further the prudent use of these drugs in the proper clinical situations by increasing our understanding of both the mechanisms of action and the clinical benefit to the patient.
Categories: Medical

Inflammatory Bowel Diseases

Inflammatory Bowel Diseases

Inflammatory Bowel Diseases and Morbus Hirschprung . Falk Symposium No. 65. ... Inflammatory Bowel Diseases – Pathophysiology as Basis of Treatment . Falk Symposium No. ... Inflammatory Bowel Diseases : New Developments and Standards .

Author: G.N. Tytgat

Publisher: Springer Science & Business Media

ISBN: 0792388941

Category: Medical

Page: 746

View: 269

There is currently an explosive growth of basic and clinical research in inflammatory bowel diseases. The extensive interest of the medical community in these diseases is largely explained by the devastating impact the illnesses have on the quality of life, their high prevalence in the community, and the fact that so many medical disciplines are involved in tackling the immensely complex studies on pathogenesis, clinical expression and treatment possibilities. The Falk Symposium No. 85 held in The Hague, the Netherlands, 29 June-1 July 1995 brought together over 80 speakers and 1000 participants from all over the world. Plenary sessions and workshops allowed the discussion of basic and clinical research, enabling appropriate choices to be made. Topics reflected areas of high current basic research interest, clinical importance, and actual or future treatment potential. Audience: An important work for all disciplines involved in research and therapy of inflammatory bowel diseases.
Categories: Medical

Advances in Inflammatory Bowel Diseases

Advances in Inflammatory Bowel Diseases

Trends in Inflammatory Bowel Disease Therapy . Falk Symposium No. 66. ... Inflammatory Bowel Diseases – Pathophysiology as Basis of Treatment . Falk Symposium No. 67. ... Inflammatory Bowel Diseases : New Developments and Standards .

Author: P. Rutgeerts

Publisher: Springer Science & Business Media

ISBN: 0792387503

Category: Medical

Page: 340

View: 823

Ulcerative colitis and Crohn's disease remain a great therapeutic challenge to the medical community. In recent years knowledge about the pathogenesis of these diseases has progressed rapidly but the cause of the diseases remains completely unknown. It has become clear that dysregulation of the mucosal immune system is the basis for the chronic evolution of the diseases in a genetically susceptible population. Exciting new therapeutic approaches have been attempted in the last couple of years and cytokine and anti-cytokine treatments in particular seem very promising, especially in intractable disease. The format of the Falk Symposium 106 on `Advances in Inflammatory Bowel Diseases', held in Brussels, Belgium, June 18-20, 1998, was somewhat innovative as each session attempted to link the new insights into pathogenetic mechanisms with new therapeutic approaches, resulting in optimal information transfer. The classic therapeutic schemes were updated with a special focus on step-wise build-up of therapy.
Categories: Medical

Hepatobiliary Diseases Cholestasis and Gallstone

Hepatobiliary Diseases  Cholestasis and Gallstone

Trends in Inflammatory Bowel Disease Therapy . Falk Symposium No. 66. ... Inflammatory Bowel Diseases - Pathophysiology as Basis of Treatment . Falk Symposium No. 67. ... Inflammatory Bowel Diseases : New Developments and Standards .

Author: M. Acalovschi

Publisher: Springer Science & Business Media

ISBN: 0792387708

Category: Medical

Page: 202

View: 124

In recent years, our knowledge about the pathogenesis, pathophysiology and treatment of hepatobiliary diseases has increased considerably. The molecular basis of cholestatic disorders as well as of gallstone disease is increasingly recognized. This has resulted in improved diagnosis, for instance in hereditary forms of intrahepatic cholestasis, and advances in treatment, for example in primary biliary cirrhosis and other chronic cholestatic disorders. This book, the proceedings of a Falk Workshop held in Cluj-Napoca, Romania, on June 9-10, 2000, brings together contributions from scientists and clinicians to highlight the most recent advances in molecular biology, pathophysiology, diagnosis and therapy of diseases of the hepatobiliary system. World experts cover a broad spectrum of topics from genetic studies to endoscopy and from medical treatment to liver transplantation.
Categories: Medical

Autoimmune Diseases in Pediatric Gastroenterology

Autoimmune Diseases in Pediatric Gastroenterology

Trends in Inflammatory Bowel Disease Therapy . Falk Symposium No. ... Inflammatory Bowel Diseases - Pathophysiology as Basis of Treatment . Falk Symposium No. ... Inflammatory Bowel Diseases : New Developments and Standards . Falk 82B .

Author: Faruk Hadziselimovic

Publisher: Springer Science & Business Media

ISBN: 0792387783

Category: Medical

Page: 304

View: 184

This book is the proceedings of the Falk Symposium No. 127 on `Autoimmune Diseases in Paediatric Gastroenterology' (IV International Falk Symposium on Paediatric Gastroenterology), held in Basel, Switzerland, on November 8-9, 2001. The symposium focused on the role of the immune system, both the acquired and the innate systems, in inflammatory bowel disease (IBD) in children and adolescents. The innate system has an important fundamental role in host defence by initiating immune responses against potentially deleterious matter. However, a mutation within the innate system may elicit an immune response against the host: hence, an autoimmune response. Chronic autoimmune hepatitis occurs predominantly in young people, and especially in women. Immunological changes are conspicuous. Tissue antibodies are found in a large number of patients. This is a disease of disordered immunoregulation marked by a deficit in suppressor T cells causing the production of autoantibodies against specific hepatocyte surface antigen. Liver membrane protein is found in the sera of patients with autoimmune chronic acute hepatitis and with primary biliary cirrhosis (PBC). The latter condition of progressive granulomatous destruction of intrahepatic bile ducts is, in many respects, analogous to the graft-versus-host syndrome where the immune system has become sensitized to foreign HLA-molecules. Primary sclerosing cholangitis (PSC) is another condition of unknown origin. All parts of the biliary tree can be involved in a chronic, fibrosing, inflammatory process that results in obliteration of the biliary tree and ultimately in biliary cirrhosis. About half of the patients also suffer from ulcerative colitis and rarely from Crohn's disease. Circulating antibodies to some antigens are found in obstructed portal tracts, as well as increased concentrations of biliary immune complexes in patients with PBC. In all three previous Falk symposia on paediatric gastroenterology, attention was focused on the role of the innate immune system in the aetiology of IBD. It has become increasingly clear in recent years that the innate system has a much more important and fundamental role in host defence. The decision to initiate an immune response is one of the major roles of the innate system. Mutations within this system could transform it into becoming constitutively active, resulting in an inflammatory reaction and thus eliciting an autoimmune response. Following an introduction to the basic phenomena of autoimmunity, the proceedings discuss clinical aspects of autoimmune diseases. In particular, current knowledge and the state of the art about the diagnosis and treatment of the autoimmune diseases of the gastrointestinal tract are described by world-renowned experts. The book also contains the short presentations on selected topics, as well as abstracts of the mini-posters read by title, which were included in the symposium.
Categories: Medical

Steatohepatitis NASH and ASH

Steatohepatitis  NASH and ASH

Trends in Inflammatory Bowel Disease Therapy . Falk Symposium No. 66. ... Inflammatory Bowel Diseases - Pathophysiology as Basis of Treatment . Falk Symposium No. 67. ... Inflammatory Bowel Diseases : New Developments and Standards .

Author: U. Leuschner

Publisher: Springer Science & Business Media

ISBN: 0792387694

Category: Medical

Page: 410

View: 995

This book is the proceedings of the Falk Symposium No. 121 on 'Steatohepatitis (NASH and ASH)', held in Den Haag, The Netherlands, on October 14-15, 2000. The histological features of what we now call non-alcoholic steatohepatitis were described as early as 1962 by the Honorary President of the Symposium, Professor Herbert Thaler, from Vienna. Others followed, and in 1980 Jürgen Ludwig, one of the speakers of this symposium, introduced the name `non-alcoholic steatohepatitis' or NASH. In a Consensus Symposium organized by the National Institute of Health (NIH) in Washington, USA, in December 1998, NASH was recognized as one of the most common liver diseases in Western countries when viral hepatitis and heavy alcohol consumption were excluded. ASH, or alcoholic steatohepatitis, is more common than NASH, since alcohol is omnipresent in Western as well as Eastern cultures. Histologically NASH and ASH are similar or even identical. Morphological findings range from fatty degeneration to inflammation and fibrosis, and may end up in liver cirrhosis. In spite of the well-defined morphological features, our knowledge of epidemiology, aetiology, and pathogenesis is full of gaps, especially for NASH. Therefore, it is the purpose of this book to show the state of the art, to discuss recent scientific data, and to suggest possible treatment strategies, hoping to stimulate clinicians as well as scientists.
Categories: Medical

Medical Imaging in Gastroenterology and Hepatology

Medical Imaging in Gastroenterology and Hepatology

Inflammatory Bowel Diseases and Morbus Hirschprung . ... Trends in Inflammatory Bowel Disease Therapy . ... Cholestatic Liver Diseases : New Strategies for Prevention and Treatment of Hepatobiliary and Cholestatic Liver Diseases ...

Author: F. Hagenmüller

Publisher: Springer Science & Business Media

ISBN: 0792387740

Category: Medical

Page: 262

View: 795

This book, the proceedings of Falk Symposium 124, `Medical Imaging in Gastroenterology and Hepatology' (Progress in Gastroenterology and Hepatology Part I), held in Hannover, Germany, on September 28-29, 2001, aims to demonstrate the newest developments in the various imaging techniques for diagnosis and therapy, coupled with overviews by renowned international experts. In this book, up-to-date technologies in medical imaging and image documentation as well as the most modern transmission techniques should bridge the gap between futuristic research and everyday clinical practice.
Categories: Medical