Epigenetics Territory and Cancer

Epigenetics Territory and Cancer

This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles.

Author: Parvin Mehdipour

Publisher: Springer

ISBN: 9789401796392

Category: Medical

Page: 539

View: 559

This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.
Categories: Medical

Telomere Territory and Cancer

Telomere Territory and Cancer

Int J Cancer 129:983–992 Pirouzpanah S, Taleban F, Atri M, Abadi A, Mehdipour P (2009) The association of plasma folate, ... Epigenetics 6:1053–1054 Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, NessaA et al (2007) Higher ...

Author: Parvin Mehdipour

Publisher: Springer Science & Business Media

ISBN: 9789400746329

Category: Medical

Page: 204

View: 944

Timing, racing, combating, struggling and targeting are some actions through which cellular fate could be reflected and evaluated. Interaction between cell territory and environment occur during pre-embryonic, fetal development, and post-natal periods. What the researchers observe as the outcome of telomeres behavior is only the peak of an ice mountain within a stormy ocean. Cellular life depends on programmed behavior of telomeres, capable to surprise the cells. Telomeres provide an introduction to the history of our cells which govern the quality of life and status of health. Telomeres as the cooperative territory are capable of stabilizing the chromosomal territory. The status of telomeres reflects the key information, announcing the real age of individuals, and may be a valuable marker for prognosis and predicting cancer. Telomere territory is characterized with a multi-disciplinary manner. Therefore, this book is aimed to offer a wide range of chapters, hoping to be useful for diverse audiences, including hematologists-oncologists, radiotherapists, surgeons, cancer researchers, and all the sectors who affect the macro- and micro- environmental domains. Finally, telomeres are sensitive, cooperative, and trustable targets. It is worth to state that ‘telomeres are messengers of NATURE’, let’s to know them as they are.
Categories: Medical

Cancer Genetics and Psychotherapy

Cancer Genetics and Psychotherapy

Clin Cancer Res 12(23):6946–6951 Margaritescu C, Raica M, Pirici D, Simionescu C, Mogoanta L, Stinga A et al (2010) Podoplanin expression in tumor-free resection margins of oral ... In: Mehdipour P (ed) Epigenetics territory and cancer.

Author: Parvin Mehdipour

Publisher: Springer

ISBN: 9783319645506

Category: Medical

Page: 1170

View: 749

The aim of this book is to provide the readers with the most comprehensive and latest accounts of research and development in this field by emphasizing on the manner of relation between doctors and cancer patients in direction of improving the patients’ style of life. This book, partly, will deal with psychotherapy by considering cancer patients, benefits, hazards and also social impacts including life style. The social supports as the key and influential paradigms will be challenged as a comparative insight by considering the global unity in order to provide a reasonable model to improve the interaction between cancer and psychological nest. In this book, the real stories of cancer patient will be also provided. The initial insight of sections includes: 1) Brief classifications and key points of clinical and histopatological aspects of each organ. 2) Brief view of genetic alterations in each organ. 3) Therapeutic aspects. 4) Brief classifications and key points of Psychology in cancer. 5) The interactions of clinical aspects with psychological field.
Categories: Medical

Epigenetics and Cancer

Epigenetics and Cancer

Chromatin conformation, nucleosome occupancy, and chromosome territory are also important epigenetic regulatory mechanisms of gene expression and cell differentiation. It is unknown whether they could be used as cancer biomarkers in the ...

Author:

Publisher: Academic Press

ISBN: 0123808650

Category: Medical

Page: 314

View: 824

Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects
Categories: Medical

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics

The basis for “full citizenship” in this territory is chronicity, which means that the cancer is controlled and contained but not cured over the long term. At this point, we are tempted to insert the grandiose phrase, “paradigm shift,” ...

Author: Gerda Egger

Publisher: Academic Press

ISBN: 9780128024928

Category: Medical

Page: 498

View: 872

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation
Categories: Medical

Dr T P Jayakrishnan s Holistic Human Metaphysics

Dr T  P  Jayakrishnan s Holistic Human Metaphysics

An Introduction to Impact of BioResonance Technology in Genetics and Epigenetics. Epigenetics Territory and Cancer. DOI: 10.1007/978-94-017-9639-2_16. 12. England JL . (2015). Dissipative adaptation in driven selfassembly.

Author: Dr. Rahul R. Nair

Publisher: Notion Press

ISBN: 9781947283831

Category: Philosophy

Page: 58

View: 790

A scientific method known as Holistic Human Metaphysics (HHM) illustrates techniques and tools to balance the energy flow in human body. By introducing the three hypotheses of HHM, the authors wish to surpass the inertia of our thinking, which is preventing mankind from giving up the conventional way of treating the human body as a machine, and to bring forth a completely novel approach to repairing and balancing the major energy centers in the human body. Source of the Content Thekkath Pappully Jayakrishnan, Rahul Raveendran Nair. Evidence-based Formulation of Three Hypotheses of Holistic Human Metaphysics, The Winnower 4:e148657.78576, 2017, DOI: 10.15200/winn.148657.78576. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License
Categories: Philosophy

Epigenetics and Metabolomics

Epigenetics and Metabolomics

Although cancer epitranscriptomics remains a largely unexplored territory, a relationship between RNA-related proteins and tumor metabolism is under scrutiny. Thus, in-depth understanding of this association and exploration of new ...

Author: Paban K. Agrawala

Publisher: Elsevier

ISBN: 9780323856539

Category: Medical

Page: 476

View: 903

Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare. Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new research Discusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among others Provides guidance in epigenomics and metabolomic research methodology
Categories: Medical

Reassessing Attachment Theory in Child Welfare

Reassessing Attachment Theory in Child Welfare

But, if you say it's epigenetic, then it comes into the same territory as cancer, infectious disease, and so it can create momentum, that I think psychological problems don't seem to be able to generate.' (Senior epigenetics researcher ...

Author: Walsh, Trish

Publisher: Policy Press

ISBN: 9781447336921

Category: Social Science

Page: 152

View: 768

This book offers an analysis and summery of the use and limitations of child attachment theory as the basis for decision-making and planning in contemporary child welfare practice. This book explores controversies related to increasing diagnoses of ‘attachment disorder’ in child welfare assessments and arguments both for and against the use of attachment specific therapies for children in care. The author calls for a new pedagogy of relational child welfare and considers the relevance of attachment theory to transnational and migrant families, refugees fleeing conflict, adoptive and surrogate children in diverse families and the increased number of families that are in poverty after the global financial crisis.
Categories: Social Science

Journal of the National Cancer Institute

Journal of the National Cancer Institute

Epigenetic Therapies Move Into New Territory , but How Exactly Do They Work ? A a a By Rabiya S. Tuma Ithough several drugs aimed at revers- tive to normal cells , and that extra methyla- tion of the tumor cells ' DNA , as predicted ing ...

Author:

Publisher:

ISBN: NYPL:33433078242439

Category: Cancer

Page:

View: 612

Categories: Cancer

Epigenetics Methods

Epigenetics Methods

(A) Breast cancer cell nuclei; the green signals represent centromere 17 and thus the number of chromosome copies; ... using a Zeiss-Apotome fluorescence microscope. chromosome territories, arm domains or gene loci became detectable, ...

Author: Trygve Tollefsbol

Publisher: Academic Press

ISBN: 9780128194157

Category: Medical

Page: 736

View: 444

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics
Categories: Medical