Epigenetics Energy Balance and Cancer

Epigenetics  Energy Balance  and Cancer

This volume of Energy Balance and Cancer provides state-of-the-art descriptions of the rapidly evolving science of epigenetics and how it may explain mechanisms by which alterations in energy balance such as obesity and physical activity ...

Author: Nathan A. Berger

Publisher: Springer

ISBN: 9783319416106

Category: Medical

Page: 271

View: 383

This volume of Energy Balance and Cancer provides state-of-the-art descriptions of the rapidly evolving science of epigenetics and how it may explain mechanisms by which alterations in energy balance such as obesity and physical activity may impact cancer. In addition to chapters explaining the processes mediating epigenetic regulation, the volume contains a series of chapters explaining how environmental influences including early life events, nutrition, exercise and microbiota may induce epigenetic changes that can affect carcinogenesis. The following chapters describe epigenetic relations of energy balance to cancer in distinct organ systems including esophagus, colon, prostate and breast. Epigenetics, Energy Balance and Cancer provides a valuable resource for students, research investigators and clinicians seeking to better understand these processes as well as a basis for novel translational and transdisciplinary approaches to further elucidate these processes and develop preventive and therapeutic strategies.
Categories: Medical

Murine Models Energy Balance and Cancer

Murine Models  Energy Balance  and Cancer

In this chapter, we will explore the possibility that development of chronic diseases such as prostate cancer are affected by ... Because prostate tissue first develops in utero, a time window when both epigenetic marks and metabolic ...

Author: Nathan A. Berger

Publisher: Springer

ISBN: 9783319167336

Category: Medical

Page: 295

View: 771

This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
Categories: Medical

Nutritional Oncology

Nutritional Oncology

Nutritional oncology is an interdisciplinary field that bridges two areas of metabolic homeostasis—nutrition and cancer. ... and nutrigenetics, genetics and epigenetics, metabolic networks, and energy balance in cancer are described.

Author: George L. Blackburn

Publisher: Elsevier

ISBN: 0080454178

Category: Medical

Page: 848

View: 538

Nutritional oncology is an increasingly active interdisciplinary field where cancer is investigated as both a systemic and local disease originating with the changes in the genome and progressing through a multi-step process which may be influenced at many points in its natural history by nutritional factors that could impact the prevention of cancer, the quality of life of cancer patients, and the risk of cancer recurrence in the rapidly increasing population of cancer survivors. Since the first edition of this book was published in 1999, the idea that there is a single gene pathway or single drug will provide a cure for cancer has given way to the general view that dietary/environmental factors impact the progression of genetic and cellular changes in common forms of cancer. This broad concept can now be investigated within a basic and clinical research context for specific types of cancer. This book attempts to cover the current available knowledge in this new field of nutritional oncology written by invited experts. This book attempts to provide not only the theoretical and research basis for nutritional oncology, but will offer the medical oncologist and other members of multidisciplinary groups treating cancer patients practical information on nutrition assessment and nutritional regimens, including micronutrient and phytochemical supplementation. The editors hope that this volume will stimulate increased research, education and patient application of the principles of nutritional oncology. NEW TO THIS EDITION: * Covers hot new topics of nutrigenomics and nutrigenetics in cancer cell growth * Includes new chapters on metabolic networks in cancer cell growth, nutrigenetics and nutrigenomics * Presents substantially revised chapters on breast cancer and nutrition, prostate cancer and nutrition, and colon cancer and nutrition * Includes new illustrations throughout the text, especially in the breast cancer chapter * Includes integrated insights into the unanswered questions and clearly defined objectives of research in nutritional oncology * Offers practical guidelines for clinicians advising malnourished cancer patients and cancer survivors on diet, nutrition, and lifestyle * Provides information on the role of bioactive substances, dietary supplements, phytochemicals and botanicals in cancer prevention and treatment
Categories: Medical

Genetics and Epigenetics of RNA Methylation System in Human Cancers

Genetics and Epigenetics of RNA Methylation System in Human Cancers

body fat rate, waist circumference, hip circumference, and energy. OBESITY. OR. CANCER. intake (Dina et al., 2007; ... with the highest expression in the hypothalamus in the region that controls energy balance, namely the arcuate ...

Author: Shicheng Guo

Publisher: Frontiers Media SA

ISBN: 9782889714476

Category: Science

Page:

View: 462

Categories: Science

Epigenetics of Exercise and Sports

Epigenetics of Exercise and Sports

Willett WC; IARC working group on energy balance and obesity. Energy balance and obesity: what are the main drivers? Cancer Causes Control. 2017;28(3):247–258. 10. McAllister EJ, Dhurandhar NV, Keith SW, et al.

Author: Stuart Raleigh

Publisher: Academic Press

ISBN: 9780128209370

Category: Medical

Page: 320

View: 605

Epigenetics of Exercise and Sports: Concepts, Methods, and Current Research explains fundamental epigenetic processes and how these are altered by exercise and sports. After a brief review of fundamental epigenetic biology, this all-new volume in the Translational Epigenetics series offers step-by-step instruction in how epigenetic factors are investigated for their influence over exercise related traits of human physiology, disease, and injury. The current state of knowledge in the field and recent findings are discussed in-depth, illuminating how exercise and sports performance may epigenetically modify our physiology, disease and injury risks, and how this knowledge can be applied in personalized exercise approaches, diagnostics, and treatment. This book also explores the shortcomings of explaining exercise related phenomena using only genomics and traditional biochemical techniques, setting the scene for a paradigm shift in exercise biology. In addition, over a dozen international specialists contribute chapters on exercise and sports epigenetics, and their influence over metabolism, obesity, aging, immunity, and neurological disease, as well as the epigenetic impacts of concussions and sports doping. A concluding chapter discusses ongoing themes in the field and outlooks for future research. Thoroughly examines fundamental concepts in exercise and sports epigenetics, methods for new research, and known impacts for human physiology, disease, and clinical outcomes Discusses exercise and sports epigenetics in relation to metabolism, obesity, aging, immunity, and neurological disease, concussion, and sports doping, among other topics Includes preliminary information on exercise epigenetics and covid-19 infection Features chapter contributions from international experts in the field
Categories: Medical

Epigenetics and Public Policy The Tangled Web of Science and Politics

Epigenetics and Public Policy  The Tangled Web of Science and Politics

As I discuss in Chapter 11 on the implications of epigenetics for cancer policy, this identification of causes for ... For example, adipose tissue itself, which was once thought to be just a passive repository in the energy balance ...

Author: Shea K. Robison

Publisher: ABC-CLIO

ISBN: 9781440844706

Category: Political Science

Page: 365

View: 773

The exciting field of epigenetics offers novel and unanticipated science-based insights into human origins and development. This book presents one of the first detailed examinations of the political implications of epigenetics. • Focuses on the latest developments in epigenetics, a subject that is attracting increased attention among scientists and researchers yet is practically unknown among policymakers and members of the general public • Explains how epigenetics works, how it is related to genetics, how it differs from conventional genetics, the different kinds of epigenetic mechanisms, and the political history of genetics and epigenetics • Addresses the latest research on epigenetics within the context of hot public policy topics such as cancer, obesity, and the environment and identifies potential policy recommendations
Categories: Political Science

Environmental Epigenetics

Environmental Epigenetics

Sex hormones, and other hormones involved in energy balance and glucose homeostasis may also contribute to the mechanisms of preeclampsiaassociated reduction in breast cancer risk (Troisi et al. 2007a).

Author: L. Joseph Su

Publisher: Springer

ISBN: 9781447166788

Category: Medical

Page: 321

View: 628

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.
Categories: Medical

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation

Cancer Res 2004;64(16):5767–74. Fang MZ, Wang Y, ... Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst ... Epigenetic mechanisms affecting regulation of energy balance: many questions, few answers.

Author: Suming Huang

Publisher: Academic Press

ISBN: 9780128004715

Category: Science

Page: 482

View: 725

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science
Categories: Science

Prognostic Epigenetics

Prognostic Epigenetics

... for T2D and glycemic traits can be investigated in key tissues for glucose homeostasis and energy balance in the body. ... cancer and/or high-grade prostatic intraepithelial neoplasia, underlining its importance for diagnosis [120].

Author:

Publisher: Academic Press

ISBN: 9780128142608

Category: Medical

Page: 442

View: 276

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook. Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime Features chapter contributions from leading international researchers
Categories: Medical

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity

Translational Epigenetics vol 4 Alexey Moskalev, Alexander Vaiserman ... SECTION 2 EARLY-LIFE EPIGENETIC PROGRAMMING OF AGING TRAJECTORIES CHAPTER 10 Early-Life Nutrition, Epigenetics, and Altered Energy Balance Later in Life.

Author: Alexey Moskalev

Publisher: Academic Press

ISBN: 9780128110836

Category: Medical

Page: 544

View: 190

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan
Categories: Medical