Cancer Epigenetics

Cancer Epigenetics

This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being de

Author: Trygve Tollefsbol

Publisher: CRC Press

ISBN: 1420045806

Category: Science

Page: 472

View: 561

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis With stand-alone chapters written by research pioneers in the field, this definitive resource covers— DNA methylation and cancer Histone modifications in cancer Emerging areas of cancer epigenetics Epigenetics in the diagnosis, prognosis, and therapy of cancer Future directions in epigenetic cancer research Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field.
Categories: Science

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics

These mutations play a causative role in the establishment of epigenetic alterations, leading to aberrant changes in DNA methylation, chromatin modifications, and nucleosome positioning. The cancer epigenome is characterized by several ...

Author: Gerda Egger

Publisher: Academic Press

ISBN: 9780128024928

Category: Medical

Page: 498

View: 630

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation
Categories: Medical

Epigenetics Territory and Cancer

Epigenetics Territory and Cancer

... MCPH1 aberrations in, 216 MicroRNA (miRNA), and breast cancer epigenetics, 112 and colorectal cancer epigenetics, 116 and hepatocellular carcinoma epigenetics, 118 and leukemia epigenetics, 120 and lung cancer epigenetics, ...

Author: Parvin Mehdipour

Publisher: Springer

ISBN: 9789401796392

Category: Medical

Page: 539

View: 181

This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.
Categories: Medical

Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention

Cancer Res. 77, 1021e1034. Davis, C.D., Ross, S.A., 2007. Dietary components impact histone modifications and cancer risk. Nutr. Rev. 65, 88e94. Dawson, M.A., Kouzarides, T., 2012. Cancer epigenetics: from mechanism to therapy.

Author: Anupam Bishayee

Publisher: Academic Press

ISBN: 9780128125663

Category: Medical

Page: 442

View: 562

Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol, and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is ideal for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies. Lists natural agents, including nutraceuticals, and their effects on normal or tumor genome Addresses various epigenetic systems and mechanisms in the regulation and support of the mammalian genome Discusses how various parts of dietary phytochemicals can influence or modify epigenetic mechanisms in several types of cancer
Categories: Medical

Epigenetics and Cancer

Epigenetics and Cancer

This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity.

Author:

Publisher: Academic Press

ISBN: 0123808677

Category: Science

Page: 394

View: 477

Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects
Categories: Science

Epigenetics and Cancer

Epigenetics and Cancer

Epigenetics is a fascinating and rapidly expanding field of modern biology. ... These advances have turned academic, medical, and public attention to the application of epigenetics to cancer prevention, diagnosis, and treatment.

Author:

Publisher: Academic Press

ISBN: 0123808650

Category: Medical

Page: 314

View: 373

Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects
Categories: Medical

Epigenetics in Cancer Mechanisms and Drug Development

Epigenetics in Cancer  Mechanisms and Drug Development

... Tao S, Li B, Xu Z, Qi Y, Wu B, Luo H and Zhu X (2022) Editorial: Epigenetics in Cancer: Mechanisms and Drug Development. ... of 14 articles contributed by more than 120 authors in the fields of cancer epigenetics and therapeutics.

Author: Xiao Zhu

Publisher: Frontiers Media SA

ISBN: 9782889743766

Category: Science

Page: 183

View: 985

Categories: Science

Epigenetics in Cancer

Epigenetics in Cancer

Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. EMBO J 2003, 22: 6335—6345. 21. ... Rouhi A, Mager DL, Humphries RK, Kuchenbauer F. MiRNAs, epigenetics, and cancer.

Author: Wiley

Publisher: John Wiley & Sons

ISBN: 9781118734391

Category: Science

Page: 174

View: 904

Epigenetics is the study of heritable changes in gene expression or cellular phenotype, caused by mechanisms other than changes in the DNA sequence. Examples include DNA methylation and histone modification. These changes may remain through cell divisions and multiple generations. Epigenetic differences among individuals may account for some of the differences between monozygotic (identical) twins. Aberrant DNA methylation is also frequently associated with human aging and diseases, such as cancer. This collection of overviews and laboratory protocols provides crucial, distilled information about the roles of epigenetics in cancer development. The overviews are geared for research scientists who need to learn more about the current understanding of epigenetic variation in humans and how the processes of DNA methylation and histone modification are regulated. The protocols give step-by-step instructions on how to detect DNA methylation using various methods such as MAPit, CHARM (arrays) and methylation-specific PCR. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the fields of genetics, genomics, and oncogenesis for students or interdisciplinary collaborators. Table of Contents: Introduction Epigenetic Variation in Humans eLS Jon F. Wilkins Genetic and Epigenetic Heterogeneity in Cancer eLS Joshua B. Stevens, Batoul Y. Abdallah, Steven D. Horne, Guo Liu, Steven W. Bremer and Henry H. Heng Techniques & Applications Mediators and Dynamics of DNA Methylation WIREs Systems Biology and Medicine Robert Shoemaker, Wei Wang and Kun Zhang DNA Methylation Alterations in Multiple Myeloma as a Model for Epigenetic Changes in Cancer WIREs Systems Biology and Medicine Amy Sharma, Christoph J. Heuck, Melissa J. Fazzari, Jayesh Mehta, Seema Singhal, John M. Greally and Amit Verma Ink4?-Arf Locus in Cancer and Aging WIREs Developmental Biology Charles J. Sherr Protocols Simultaneous Single-Molecule Mapping of Protein-DNA Interactions and DNA Methylation by MAPit Current Protocols in Molecular Biology Carolina E. Pardo, Russell P. Darst, Nancy H. Nabilsi, Amber L. Delmas and Michael P. Kladde Comprehensive High-Throughput Arrays for Relative Methylation (CHARM) Current Protocols in Human Genetics Christine Ladd-Acosta, Martin J. Aryee, Jared M. Ordway and Andrew P. Feinberg Methylation-specific PCR Current Protocols in Human Genetics Bradford Coffee
Categories: Science

Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development Progression and Treatment

Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development  Progression  and Treatment

Epigenetic regulation of immune checkpoints: another target for immunotherapy? Immunotherapy. (2017) 9:99–108. doi: 10.2217/imt-2016-0111 4. Easwaran H, Tsai HC, Baylin SB. Cancer epigenetics: tumor heterogeneity, plasticity of ...

Author: Katherine Chiappinelli

Publisher: Frontiers Media SA

ISBN: 9782889717309

Category: Medical

Page:

View: 925

Categories: Medical

Epigenetics

Epigenetics

Kristensen LS, Nielsen HM & Hansen LL (2009) Epigenetics and cancer treatment. Eur J Pharmacol 625:131–142 (doi:10.1016/j.ejphar.2009.10.011). Lopez-Serra P & Esteller M (2012) DNA methylation-associated silencing of tumor-suppressor ...

Author: Lyle Armstrong

Publisher: Garland Science

ISBN: 9781000319736

Category: Science

Page: 300

View: 227

The concept of epigenetics has been known about since the 1940s, but it is only in the last 10 years that research has shown just how wide ranging its effects are. It is now a very widely-used term, but there is still a lot of confusion surrounding what it actually is and does.Epigenetics is a new textbook that brings together the structure and mac
Categories: Science