This volume, together with Innovations in Organic Synthesis provides complete coverage of over 40 years of organopalladium chemistry.
Author: Jiro Tsuji
Publisher: John Wiley & Sons
Jiro Tsuji, one of the pioneers in this field of organic synthesis, provides synthetic organic chemists with a remarkable overview of the many applications of organopalladium chemistry. Tsuji discusses the recent developments in the field as well as the explosive growth over the last five years. Highlighting the most recent discoveries in this rapidly expanding field, the book; Focuses on new aspects of organopalladium chemistry, putting emphasis on synthetic applications Investigates the new perspectives on the synthetic uses of contemporary organopalladium chemistry This volume, together with Innovations in Organic Synthesis, Tsuji's previous title, provides complete coverage of over 40 years of organopalladium chemistry. Palladium Reagents and Catalysts: New Perspectives for the 21st Century is an essential reference source and companion for students, and both industrial and academic research chemists working in organic synthesis, particularly on synthesis of natural products and medicinal compounds. Those studying development of new synthetic methodology and organometallic chemistry will also find this book valuable.
L. Brandsma has carefully selected and checked the experimental procedures illustrating the catalytic use of copper, nickel, and palladium compounds in organic synthesis.
Author: L. Brandsma
Publisher: Springer Science & Business Media
Homogeneous catalysis is an important strategy for the synthesis of high-valued chemicals. L. Brandsma has carefully selected and checked the experimental procedures illustrating the catalytic use of copper, nickel, and palladium compounds in organic synthesis. All procedures are on a preparative scale, make economic use of solvents and catalysts, avoid toxic substances and have high yields.
This book should hold particular interest for those who apply palladium reagents and catalysts to organic synthesis; in fact, palladium is considered by many to be the most useful transition element employed for organic syntheses.
Author: J. Tsuji
Publisher: Elsevier Science Limited
Perspectives in Organopalladium Chemistry for the 21st Century is a monograph on modern organopalladium chemistry, with an emphasis on the use of palladium in organic synthesis. The collection of articles is reprinted from a special issue of the Journal of Organometallic Chemistry. The field of organopalladium chemistry is evolving rapidly, building on a growing catalogue of reactions that employ palladium-containing catalysts. This book should hold particular interest for those who apply palladium reagents and catalysts to organic synthesis; in fact, palladium is considered by many to be the most useful transition element employed for organic syntheses. This selection of articles by leading scientists, published as "Perspectives in Organopalladium Chemistry for the 21st Century", provides an impressive overview of the field that every chemist who works with organometallic palladium catalysts should read.
Kocovsky, P., Malkov, A. V., Vyskocil, S., Lloyd-Jones, G. C. Transition metal catalysis in organic synthesis: reflections, chirality and new vistas. Pure Appl. Chem. 1999, 71, 1425-1433. Li, J. J. Applications of palladium chemistry to ...
Author: Laszlo Kurti
Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings
Curr. Chem., 1980, 91, 29–74. Application of Palladium Catalyzed or Promoted Reactions to Natural Products Synthesis. B. M. Trost, Aldrichimica Acta, 1981, 14, 43–50. Transtition-Metal Templates for Selectivity in Organic Synthesis.
The book explains that palladium (II) can induce C-O bond formation. These reactions involve oxidation of the organic substrate and reduces the Pd(II) to metal, and are not catalytic.
Author: Peter Maitlis
The Organic Chemistry of Palladium, Volume I1: Catalytic Reactions deals with organic transformations resulting from palladium complexes either stoichiometrically or catalytically. One feature of a reaction catalyzed by transition metals is the absence of evidence for the typical reactive intermediates of organic chemistry, carbanions, and carbonium ions. This lack of evidence is due to the metal acting both as a source and a sink of electrons that result in energetically unfavorable ionic intermediaries. The book explains that palladium (II) can induce C-O bond formation. These reactions involve oxidation of the organic substrate and reduces the Pd(II) to metal, and are not catalytic. Industrial applications can re-oxidize the palladium metal back to Pd(II) in situ, making the reactions catalytic. The text also discusses certain reactions that can form C-O bonds as part of an oxidative process. The book also describes significant reactions that can be catalyzed by palladium metal, such as in the hydrogenation of multiple bonds, in the carbonylation of certain olefins and acetylenes, and in the catalytic cracking of high molecular weight hydrocarbons. Organic chemists, analytical chemists, investigators, and scientists whose works involve physical or inorganic chemistry will find the book truly useful.
For this second edition the text has been extensively revised and expanded to reflect the significant improvements and advances in the field since the first edition, as well as the large number of new transition metal-catalysed processes ...
Author: Roderick Bates
Publisher: John Wiley & Sons
Transition metals open up new opportunities for synthesis, becausetheir means of bonding and their reaction mechanisms differ fromthose of the elements of the s and p blocks. In the last twodecades the subject has mushroomed - established reactions areseeing both technical improvements and increasing numbers ofapplications, and new reactions are being developed. Thepracticality of the subject is demonstrated by the large number ofpublications coming from the process development laboratories ofpharmaceutical companies, and its importance is underlined by thefact that three Nobel prizes have been awarded for discoveries inthis field in the 21st Century already. Organic Synthesis Using Transition Metals, 2nd Editionconsiders the ways in which transition metals, as catalysts andreagents, can be used in organic synthesis, both for pharmaceuticalcompounds and for natural products. It concentrates on thebond-forming reactions that set transition metal chemistry apartfrom "classical" organic chemistry. Each chapter isextensively referenced and provides a convenient point of entry tothe research literature. Topics covered include: introduction to transition metals in organic synthesis coupling reactions C-H activation carbonylative coupling reactions alkene and alkyne insertion reactions electrophilic alkene and alkyne complexes reactions of alkyne complexes carbene complexes spanstyle="font-family: Symbol; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Arial; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"h/span3-or spanstyle="font-family: Symbol; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Arial; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"p/span-allyl-allyl complexes diene, dienyl and arene complexes cycloaddition and cycloisomerisation reactions For this second edition the text has been extensively revisedand expanded to reflect the significant improvements and advancesin the field since the first edition, as well as the large numberof new transition metal-catalysed processes that have come toprominence in the last 10 years – for example theextraordinary progress in coupling reactions using“designer” ligands, catalysis using gold complexes, newopportunities arising from metathesis chemistry, and C-H activation– without neglecting the well established chemistry of metalssuch as palladium. Organic Synthesis Using Transition Metals, 2nd Editionwill find a place on the bookshelves of advanced undergraduates andpostgraduates working in organic synthesis, catalysis, medicinalchemistry and drug discovery. It is also useful for practisingresearchers who want to refresh and enhance their knowledge of thefield.
Therefore, the my work focused on the synthesis of precatalysts with an established 1:1 L:Pd. Specifically, we were focused on the synthesis of mono-ligated palladium(II) precatalysts of general formula [(R_3P)PdCl_2]_2, using di-tert ...
Author: Kerry Lynn Barnett
Palladium catalyzed cross-coupling reactions are a versatile tool in organic chemistry to produce small molecules. Current research interests involve the development of new catalyst systems for various palladium catalyzed reactions. Previous work has suggested the active species for palladium-catalyzed cross-coupling reactions to be a mono-ligated palladium(0) species when sterically demanding ligands are used. Therefore, the my work focused on the synthesis of precatalysts with an established 1:1 L:Pd. Specifically, we were focused on the synthesis of mono-ligated palladium(II) precatalysts of general formula [(R_3P)PdCl_2]_2, using di-tert-butylneopentylphosphine (DTBNpP), tert-butyldineopentylphosphine (TBDNpP), and trineopentylphosphine (TNpP) as ligands. Under optimized conditions, both [(DTBNpP)PdCl_2]_2 and [(TNpP)PdCl_2]_2 were effective precatalysts for the Suzuki cross-coupling of a wide range of aryl bromides. Comparison studies with the air-stable precatalysts versus the in-situ generated catalyst showed the precatalysts to have improved conversions and higher rates of reaction under both inert and ambient atmospheres. The precatalyst activation pathways were investigated by 31P NMR spectroscopy. The spectra obtained from 31P NMR experiments revealed a side reaction resulting in a catalytically inactive palladacycle species. The results obtained from the mechanistic investigations led to further optimization of reaction conditions to decrease the amounts of catalytically inactive side products formed.